The Holiday Inn Express Hotel and Suites Vermillion sits just off Highway 50 and offers a convenient location for every traveler. Enjoy free Wi-Fi, a spa and heated pool, a fitness center, laundry facilities and meeting room. Kick back and relax in our well-appointed rooms designed for your comfort. After a long day, unwind with a massaging shower and sleep in the cozy, triple-sheeted bedding. We’re across the street from the Dakota Dome and minutes from the University of South Dakota campus.